ALSUntangled 59: Tamoxifen

Amyotroph Lateral Scler Frontotemporal Degener. 2021 Nov;22(7-8):595-598. doi: 10.1080/21678421.2021.1876731. Epub 2021 Jan 21.

Abstract

Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.

Keywords: ALSUntangled; Tamoxifen; clinical trials; ethics; off-label treatment; therapy; trials.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis* / drug therapy
  • Humans
  • Tamoxifen* / therapeutic use

Substances

  • Tamoxifen