Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis

Ludovico Luca Sicignano; Maria Grazia Massaro; Marinica Savino; Donato Rigante; Laura Gerardino; Raffaele Manna

doi:10.1007/s11739-020-02627-2

Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis

Intern Emerg Med. 2021 Aug;16(5):1391-1394. doi: 10.1007/s11739-020-02627-2. Epub 2021 Jan 21.

Authors

Ludovico Luca Sicignano^{1

2}, Maria Grazia Massaro¹, Marinica Savino³, Donato Rigante^{2

4}, Laura Gerardino^{1

2}, Raffaele Manna^{5

6}

Affiliations

¹ Institute of Internal Medicine, Periodic Fever and Rare Diseases Research Centre, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
² Università Cattolica Sacro Cuore, Rome, Italy.
³ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
⁴ Department of Life Sciences and Public Health, Periodic Fever and Rare Diseases Research Centre, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
⁵ Institute of Internal Medicine, Periodic Fever and Rare Diseases Research Centre, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy. [email protected].
⁶ Università Cattolica Sacro Cuore, Rome, Italy. [email protected].

Abstract

The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.

Publication types

Letter

MeSH terms

Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Cardiac Tamponade / drug therapy
Cardiac Tamponade / prevention & control*
Humans
Interleukin 1 Receptor Antagonist Protein / pharmacology*
Interleukin 1 Receptor Antagonist Protein / therapeutic use
Male
Pericarditis / drug therapy*
Pericarditis / physiopathology
Sepsis / drug therapy
Sepsis / prevention & control
Staphylococcal Infections / complications
Staphylococcal Infections / drug therapy

Substances

Anti-Bacterial Agents
Interleukin 1 Receptor Antagonist Protein