Faster Initial Viral Decay in Female Children Living With HIV

Sara Domínguez-Rodríguez; Miquel Serna-Pascual; Caroline Foster; Paolo Palma; Eleni Nastouli; Anita De Rossi; Javier Seoane; Paolo Rossi; Carlo Giaquinto; Alfredo Tagarro; Pablo Rojo

doi:10.1093/jpids/piaa174

Faster Initial Viral Decay in Female Children Living With HIV

J Pediatric Infect Dis Soc. 2021 May 28;10(5):674-676. doi: 10.1093/jpids/piaa174.

Authors

Affiliations

¹ Pediatric Infectious Diseases Unit, Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain.
² Imperial College Healthcare NHS Trust, London, UK.
³ Division of Immune and Infectious Diseases, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy.
⁴ Department of Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.
⁵ Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Padova, Italy.
⁶ Terrestrial Ecology Group, Department of Ecology, Universidad Autónoma de Madrid, Madrid, Spain.

PMID: 33491084
DOI: 10.1093/jpids/piaa174

Abstract

Limited data exist regarding sex bias and viral decay in children with HIV. We investigated the sex differences in viral decay in 25 perinatally HIV-infected children. Females presented faster phase I viral decay regardless of their age at antiretroviral therapy (ART) initiation, baseline CD4 percentages, or baseline RNA levels. Also, for each month elapsed under ART, females had faster viral decay than males.

Keywords: HIV-1; pediatrics; reservoir; sex; viral decay.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].

MeSH terms

Anti-HIV Agents* / therapeutic use
Child
Female
HIV Infections* / drug therapy
HIV-1*
Humans
Male
Viral Load*

Substances

Anti-HIV Agents