Oral S-ketamine effective after deep brain stimulation in severe treatment-resistant depression and extensive comorbidities

BMJ Case Rep. 2021 Jan 25;14(1):e238135. doi: 10.1136/bcr-2020-238135.

Abstract

This case report describes successful maintenance treatment with oral S-ketamine in a patient with severe depression, who previously was resistant to electroconvulsive therapy and deep brain stimulation, and who also had comorbid psychotic and obsessive compulsive symptoms.

Keywords: depressive disorder; therapeutic indications.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / therapeutic use*
  • Antipsychotic Agents / therapeutic use
  • Clozapine / therapeutic use
  • Deep Brain Stimulation
  • Depressive Disorder, Treatment-Resistant / complications
  • Depressive Disorder, Treatment-Resistant / drug therapy*
  • Depressive Disorder, Treatment-Resistant / psychology
  • Depressive Disorder, Treatment-Resistant / therapy
  • Electroconvulsive Therapy
  • Female
  • Glycopyrrolate / therapeutic use
  • Hallucinations / complications
  • Hallucinations / psychology
  • Humans
  • Ketamine / therapeutic use*
  • Middle Aged
  • Muscarinic Antagonists / therapeutic use
  • Nitrazepam / therapeutic use
  • Obsessive-Compulsive Disorder / complications
  • Obsessive-Compulsive Disorder / psychology
  • Treatment Failure
  • Venlafaxine Hydrochloride / therapeutic use

Substances

  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antipsychotic Agents
  • Muscarinic Antagonists
  • Esketamine
  • Ketamine
  • Venlafaxine Hydrochloride
  • Nitrazepam
  • Clozapine
  • Glycopyrrolate