Abstract
Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.
Keywords:
COVID-19; SARS-CoV-2; SARS-CoV-2 spike protein; asymptomatic coronavirus disease; immune response; neutralizing antibodies; respiratory infections; viruses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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Asymptomatic Infections
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COVID-19 / blood
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COVID-19 / immunology*
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COVID-19 / virology
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Child
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Female
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Humans
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Immunity, Humoral*
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Longitudinal Studies
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Male
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Middle Aged
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Nucleocapsid Proteins / blood
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Nucleocapsid Proteins / immunology
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SARS-CoV-2 / immunology*
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Spike Glycoprotein, Coronavirus / blood
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Spike Glycoprotein, Coronavirus / immunology
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Time Factors
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Vietnam
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Young Adult
Substances
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Antibodies, Viral
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Nucleocapsid Proteins
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Spike Glycoprotein, Coronavirus