Ewing's Sarcoma

N Engl J Med. 2021 Jan 14;384(2):154-164. doi: 10.1056/NEJMra2028910.

Authors

Nicolò Riggi¹, Mario L Suvà¹, Ivan Stamenkovic¹

Affiliation

¹ From the Institute of Pathology, Faculty of Biology and Medicine, University of Lausanne and Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (N.R., I.S.); and the Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, and the Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge - both in Massachusetts (M.L.S.).

PMID: 33497548
DOI: 10.1056/NEJMra2028910

No abstract available

Publication types

Review

MeSH terms

Antineoplastic Agents / therapeutic use
Bone Neoplasms* / genetics
Bone Neoplasms* / therapy
Combined Modality Therapy
DNA Methylation
DNA, Neoplasm / metabolism
Gene Expression Regulation
Humans
Mutation
Oncogene Proteins, Fusion / metabolism*
Polymorphism, Genetic
Prognosis
Proto-Oncogene Protein c-fli-1 / metabolism*
RNA-Binding Protein EWS / metabolism*
Sarcoma, Ewing* / genetics
Sarcoma, Ewing* / therapy
Suppression, Genetic
Translocation, Genetic

Substances

Antineoplastic Agents
DNA, Neoplasm
EWS-FLI fusion protein
Oncogene Proteins, Fusion
Proto-Oncogene Protein c-fli-1
RNA-Binding Protein EWS