Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

Int J Antimicrob Agents. 2021 Mar;57(3):106293. doi: 10.1016/j.ijantimicag.2021.106293. Epub 2021 Jan 27.
No abstract available

Publication types

  • Letter

MeSH terms

  • Aged
  • COVID-19 Drug Treatment*
  • Chloroquine / adverse effects*
  • Chloroquine / analogs & derivatives*
  • Chloroquine / blood
  • Chloroquine / pharmacokinetics*
  • Chloroquine / therapeutic use
  • Electrocardiography
  • Female
  • Humans
  • Long QT Syndrome / chemically induced*
  • Male
  • Middle Aged
  • SARS-CoV-2 / drug effects

Substances

  • Chloroquine
  • desethylchloroquine