CD225 Proteins: A Family Portrait of Fusion Regulators

Trends Genet. 2021 May;37(5):406-410. doi: 10.1016/j.tig.2021.01.004. Epub 2021 Jan 29.

Abstract

The CD225 superfamily regulates vesicular membrane fusion events essential to neurotransmission, immunity, development, and metabolism. Its importance to physiology is reinforced by the identification of polymorphisms associated with disease. This article highlights the shared features that drive the function of CD225 proteins such as interferon-inducible transmembrane proteins 3 (IFITM3) and proline-rich transmembrane protein 2 (PRRT2) and is intended to catalyze efforts towards characterizing the lesser-known family members.

Keywords: CD225; IFITM; PRRT2; TUSC5; fusion; transmembrane.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Antigens, Differentiation / chemistry
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / metabolism*
  • Exocytosis / physiology
  • Host-Pathogen Interactions / immunology
  • Humans
  • Membrane Fusion / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / immunology
  • Membrane Proteins / metabolism*
  • Multigene Family
  • Nerve Tissue Proteins / metabolism*
  • Virus Internalization

Substances

  • Antigens, Differentiation
  • Membrane Proteins
  • Nerve Tissue Proteins
  • PRRT2 protein, human
  • fragilis protein, mouse
  • leu-13 antigen