Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy

Yin Xiao; Yuhong Gu; Li Qin; Lin Chen; Xiaoliang Chen; Weiheng Cui; Fuling Li; Ni Xiang; Xiaoai He

doi:10.1016/j.colsurfb.2021.111581

Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy

Colloids Surf B Biointerfaces. 2021 Apr:200:111581. doi: 10.1016/j.colsurfb.2021.111581. Epub 2021 Jan 16.

Authors

Yin Xiao¹, Yuhong Gu², Li Qin³, Lin Chen⁴, Xiaoliang Chen⁵, Weiheng Cui⁶, Fuling Li⁷, Ni Xiang⁸, Xiaoai He⁹

Affiliations

¹ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
² Center for Governmental Hospital Management, Ordos Health Commission, Ordos, 017000, China. Electronic address: [email protected].
³ Shandong Provincial Key Laboratory of Microparticles Drug Delivery Technology, Jinan, 250100, China. Electronic address: [email protected].
⁴ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
⁵ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
⁶ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
⁷ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
⁸ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].
⁹ Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570100, China. Electronic address: [email protected].

PMID: 33524696
DOI: 10.1016/j.colsurfb.2021.111581

Abstract

Injectable thermosensitive hydrogel has been regarded as attractive drug delivery system, which displays a sol-gel phase transition upon injection in response to temperature. Recently, thermosensitive hydrogel has become a matter of importance in cancer therapy, providing high local drug concentration, sustained release characteristics, minimal invasiveness, and low systemic toxicities. Here, we review the extensive application of thermosensitive hydrogel in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.

Keywords: Cancer therapy; Drug delivery system; Thermosensitive hydrogel.

Publication types

Review

MeSH terms

Drug Delivery Systems
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate
Hydrogels* / therapeutic use
Injections
Neoplasms* / drug therapy
Temperature

Substances

Hydrogels
Hydrogel, Polyethylene Glycol Dimethacrylate