Training the metaorganism: the microbial counterpart

Irah L King; Maziar Divangahi

doi:10.1016/j.cell.2021.01.009

Training the metaorganism: the microbial counterpart

Cell. 2021 Feb 4;184(3):574-576. doi: 10.1016/j.cell.2021.01.009.

Authors

Irah L King¹, Maziar Divangahi²

Affiliations

¹ Meakins-Christie Laboratories, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
² Meakins-Christie Laboratories, Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada; Department of Medicine, Department of Pathology, McGill International TB Centre, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address: [email protected].

PMID: 33545033
DOI: 10.1016/j.cell.2021.01.009

Abstract

Infection or immunization can reprogram innate immune cells generating memory responses with broad protection against subsequent infection, a process referred to as "trained immunity." A new study by Stacy and colleagues demonstrates that, following acute infection, the commensal microbiota can also be "trained" to enhance colonization resistance against heterologous infection.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Immunity, Innate
Immunization
Infections*
Microbiota*
Symbiosis

Grants and funding

CIHR/Canada