Backgrounds: There is an increasing number of cases of two-stage surgery for synchronous or metachronous lung cancer. We discuss the surgical treatment strategy for multiple lung cancers.
Methods: We retrospectively reviewed the clinicopathological factors and prognosis of 105 patients (210 surgeries) who underwent two-stage surgery for lung cancer during the period from 2010 to 2019 in our department.
Results: A total of 105 cases were reviewed;58 males and 47 females, 67 were synchronous and 38 were metachronous. Long-term prognosis of death from other diseases due to respiratory diseases was found in eight patients (7.6%). Recurrence of lung cancer was observed in 29 (27.6%), and cancer death was found in 9 of them. The overall three-year and five-year survival rates were 85.3% and 71.3 %, respectively. The absence of ground-glass opacity components in the tumor( p=0.036) and advanced pathological stage( p=0.048) were significantly associated with postoperative recurrence.
Conclusions: The recurrence rate was high in cases of solid tumors and advanced pathological stage, even in multiple lung cancers. Thus, an appropriate combination of limited surgery and standard surgery should be used, taking into account the nature of the tumor and the patient's ability to tolerate the surgery.