Two new cases of multiple biliary papillomatosis are reported. In these 2 cases, endoscopic retrograde cholangiography (CRE) was performed; the roentgen findings are described; the mucinous aspect of the bile, the important levels of biliary carcinoembryonic antigen and the intraductal biopsies after endoscopic sphincterotomy (E.S.) furnished precious aid for diagnosis; one E.S. was performed in the two cases allowing satisfactory drainage biliary; in one case, surgery and chemotherapy were associated; based on these two cases and 26 others of literature, management of the disease is discussed.