Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease

Affiliations

• ¹ Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark.
• ² AbbVie Deutschland GmbH & Co.KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.
• ³ Cajal Institute-CSIC and CIBERNED-ISCIII, Madrid, Spain.
• ⁴ Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937 Cologne, Germany.
• ⁵ Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937 Cologne, Germany; Department of Neurodegeneration and Geriatric Psychiatry, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
• ⁶ Department of Neurodegeneration and Geriatric Psychiatry, University of Bonn, 53127 Bonn, Germany.
• ⁷ Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty and University Hospital Bonn, Bonn 53127, Germany.
• ⁸ Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Faculty and University Hospital Bonn, Bonn 53127, Germany; Cell Programming Core Facility, University of Bonn Medical Faculty, Bonn, Germany.
• ⁹ Janssen Research & Development, Neuroscience Therapeutic Area (Johnson & Johnson), Turnhoutseweg 30, 2340 Beerse, Belgium.
• ¹⁰ Janssen Research & Development, Neuroscience Therapeutic Area (Johnson & Johnson), Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: [email protected].