Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):e193-e207. doi: 10.1161/ATVBAHA.121.315900. Epub 2021 Feb 11.

Abstract

[Figure: see text].

Keywords: endothelial cells; heart failure; histamine; inflammation; mast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Degranulation*
  • Cells, Cultured
  • Coronary Vessels / immunology
  • Coronary Vessels / metabolism*
  • Coronary Vessels / pathology
  • Diabetes Mellitus* / genetics
  • Diabetes Mellitus* / immunology
  • Diabetes Mellitus* / metabolism
  • Diastole
  • Disease Models, Animal
  • Female
  • Heart Failure / etiology*
  • Heart Failure / immunology
  • Heart Failure / metabolism
  • Heart Failure / physiopathology
  • Histamine Release
  • Humans
  • Mast Cells / immunology
  • Mast Cells / metabolism*
  • Mast Cells / pathology
  • Mice
  • Mice, Knockout
  • Myocardium / immunology
  • Myocardium / metabolism
  • Myocardium / pathology
  • Obesity / complications*
  • Obesity / immunology
  • Obesity / metabolism
  • Receptors, Leptin / deficiency
  • Receptors, Leptin / genetics
  • Ventricular Dysfunction, Left / etiology*
  • Ventricular Dysfunction, Left / immunology
  • Ventricular Dysfunction, Left / metabolism
  • Ventricular Dysfunction, Left / physiopathology
  • Ventricular Function, Left*

Substances

  • Receptors, Leptin
  • leptin receptor, mouse