Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post-unrelated HCT

Blood Adv. 2021 Jan 12;5(1):66-70. doi: 10.1182/bloodadvances.2020003366.

Abstract

  1. Pre-HCT mosaicism is related to increased relapse risk and lower survival after unrelated HCT, independent of cytogenetics at diagnosis.

  2. Pre-HCT mosaicism could be a useful clinical tool to guide risk stratification in acute lymphoblastic leukemia patients.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Mosaicism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Recurrence
  • Transplantation, Homologous