Locally advanced rectal adenocarcinoma: Treatment sequences, intensification, and rectal organ preservation

CA Cancer J Clin. 2021 May;71(3):198-208. doi: 10.3322/caac.21661. Epub 2021 Feb 16.

Authors

Alec Bigness¹, Iman Imanirad², Ibrahim Halil Sahin², Hao Xie², Jessica Frakes³, Sarah Hoffe³, Danielle Laskowitz⁴, Seth Felder⁴

Affiliations

¹ University of South Florida Morsani College of Medicine, Tampa, Florida.
² Department of Gastrointestinal Oncology, Medical Oncology Section, H. Lee Moffitt Cancer Center, Tampa, Florida.
³ Department of Gastrointestinal Oncology, Radiation Oncology Section, H. Lee Moffitt Cancer Center, Tampa, Florida.
⁴ Department of Gastrointestinal Oncology, Surgical Oncology Section, H. Lee Moffitt Cancer Center, Tampa, Florida.

PMID: 33592118
DOI: 10.3322/caac.21661

No abstract available

Publication types

Case Reports

MeSH terms

Adenocarcinoma / diagnostic imaging
Adenocarcinoma / pathology*
Adenocarcinoma / therapy*
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Capecitabine / administration & dosage
Carcinoembryonic Antigen / blood
Chemoradiotherapy
Fluorouracil / therapeutic use
Humans
Induction Chemotherapy
Leucovorin / therapeutic use
Magnetic Resonance Imaging
Male
Neoadjuvant Therapy
Neoplasm Invasiveness
Neoplasm Staging
Neoplasm, Residual
Organ Sparing Treatments
Organoplatinum Compounds / therapeutic use
Proctectomy
Rectal Neoplasms / diagnostic imaging
Rectal Neoplasms / pathology*
Rectal Neoplasms / therapy*

Substances

Carcinoembryonic Antigen
Organoplatinum Compounds
Capecitabine
Leucovorin
Fluorouracil

Supplementary concepts

Folfox protocol