Long-standing Multifocal Motor Neuropathy Presenting With Delayed Clinical Features of Anti-Myelin-Associated Glycoprotein Neuropathy and Elevated Anti-Myelin-Associated Glycoprotein Antibody Titers

J Clin Neuromuscul Dis. 2021 Mar 1;22(3):169-172. doi: 10.1097/CND.0000000000000334.

Abstract

Multifocal motor neuropathy with conduction block (MMN) and anti-myelin-associated glycoprotein (MAG) neuropathy are rare chronic acquired demyelinating neuropathies with distinct clinical and electrophysiological characteristics. These neuropathies are generally not known to coexist. This report describes a patient with long-standing MMN who subsequently developed clinical features of anti-MAG neuropathy. This suggests that subtypes of chronic inflammatory neuropathies may not be sharply defined. In addition, a presentation of MMN with anti-MAG titers may be a prognostic indicator of poor response to standard MMN treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies / metabolism*
  • Electromyography
  • Humans
  • Immunoglobulin M / metabolism
  • Male
  • Myelin-Associated Glycoprotein / metabolism*
  • Neural Conduction
  • Polyneuropathies / diagnosis*

Substances

  • Antibodies
  • Immunoglobulin M
  • MAG protein, human
  • Myelin-Associated Glycoprotein