Intravenous to Oral Switch in Complicated Staphylococcus aureus Bacteremia Without Endovascular Infection: A Retrospective Single-Center Cohort Study

Ilse J E Kouijzer; Eline J van Leerdam; Michelle Gompelman; Renee A M Tuinte; Erik H J G Aarntzen; Marvin A H Berrevoets; Ianthe Maat; Chantal P Bleeker-Rovers; Reinout van Crevel; Jaap Ten Oever

doi:10.1093/cid/ciab156

Intravenous to Oral Switch in Complicated Staphylococcus aureus Bacteremia Without Endovascular Infection: A Retrospective Single-Center Cohort Study

Clin Infect Dis. 2021 Sep 7;73(5):895-898. doi: 10.1093/cid/ciab156.

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
² Department of Gastroenterology and Hepatology, Radboud university medical center, Nijmegen, The Netherlands.
³ Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴ Department of Internal Medicine, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
⁵ Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

Abstract

In this retrospective cohort study, selected patients with disseminated Staphylococcus aureus bacteremia, but without endovascular infection on echocardiography and 18F-FDG-PET/CT, were free of relapse after IV-oral switch. Mortality was low and similar to patients who received prolonged intravenous treatment. IV-oral switch was associated with a shorter length of hospital stay.

Keywords: IV-oral switch; Staphylococcus aureus; bacteremia; treatment.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Bacteremia* / drug therapy
Cohort Studies
Humans
Positron Emission Tomography Computed Tomography
Retrospective Studies
Staphylococcal Infections* / drug therapy
Staphylococcus aureus

Substances

Anti-Bacterial Agents