Shining a Light on Phenotypic Drug Discovery

Ku-Lung Hsu

doi:10.1016/j.chembiol.2021.01.020

Shining a Light on Phenotypic Drug Discovery

Cell Chem Biol. 2021 Feb 18;28(2):115-117. doi: 10.1016/j.chembiol.2021.01.020.

Author

Ku-Lung Hsu¹

Affiliation

¹ Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA; University of Virginia Cancer Center, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: [email protected].

Abstract

In this issue of Cell Chemical Biology, Seneviratne et al. (2020) combine photoaffinity labeling and quantitative chemical proteomics to identify the molecular target of a lead compound discovered from a phenotypic drug screen. Their work showcase the power of coupling a photoreactive group to screening hits for rapid target deconvolution.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Drug Discovery*
Photoaffinity Labels*
Proteomics

Substances

Photoaffinity Labels

Grants and funding

R01 DA043571/DA/NIDA NIH HHS/United States