Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines

Sarwar Beg; Waleed H Almalki; Fahmida Khatoon; Khalid S Alharbi; Saad Alghamdi; Md Habban Akhter; Habibullah Khalilullah; Abdullah A Baothman; Abdul Hafeez; Mahfoozur Rahman; Sohail Akhter; Hani Choudhry

doi:10.1016/j.drudis.2021.02.013

Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines

Drug Discov Today. 2021 Aug;26(8):1891-1903. doi: 10.1016/j.drudis.2021.02.013. Epub 2021 Feb 18.

Authors

Affiliations

¹ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Electronic address: [email protected].
² Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
³ Department of Biochemistry, College of Medicine, University of Hail, Saudi Arabia.
⁴ Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia.
⁵ Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
⁶ Faculty of Pharmacy, DIT University, Dehradun, India.
⁷ Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia.
⁸ Ministry of National Guard-Health Affairs, King Saud Bin Abdulaziz University for Health Science (KSAU-HS), King Abdullah International Medical Research Center (KAIMARC), Saudi Arabia.
⁹ Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Sahranpur, Uttar Pradesh, India.
¹⁰ Department of Pharmaceutical Sciences, SIHAS, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India. Electronic address: [email protected].
¹¹ New Product Development, Global R&D, Sterile ops, TEVA Pharmaceutical Industries Ltd., Aston Ln N, Halton, Preston Brook, Runcorn WA7 3FA, UK; Centre de Biophysique Moléculaire, CNRS UPR4301, Rue Charles Sadron, 45071 Orléans Cedex 2, France.
¹² Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.

PMID: 33610757
DOI: 10.1016/j.drudis.2021.02.013

Abstract

Cancer vaccines consist of nucleic acid derivatives such as plasmid DNA, small interfering RNA and mRNA, and can be customized according to the patient's needs. Nanomedicines have proven to be exceptionally good as miniaturized drug carriers, and thus they offer great advantages for delivering cancer vaccines. This review provides an overview of the literature on cancer vaccines, from their inception to current developments in the field.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cancer Vaccines / administration & dosage*
DNA / administration & dosage
Humans
Lipids / chemistry
Nanoparticles
Neoplasms / therapy*
Nucleic Acid-Based Vaccines / administration & dosage*
Plasmids
Polymers / chemistry
RNA, Messenger / administration & dosage
RNA, Small Interfering / administration & dosage

Substances

Cancer Vaccines
Lipids
Nucleic Acid-Based Vaccines
Polymers
RNA, Messenger
RNA, Small Interfering
DNA