Objective: To summarize the expression and role of CD146 in mesenchymal stem cells (MSCs).
Methods: The literature related to CD146 at home and abroad were extensively consulted, and the CD146 expression in MSCs and its function were summarized and analyzed.
Results: CD146 is a transmembrane protein that mediates the adhesion of cells to cells and extracellular matrix, and is expressed on the surface of various MSCs. More and more studies have shown that CD146 + MSCs have superior cell properties such as greater proliferation, differentiation, migration, and immune regulation abilities than CD146 - or unsorted MSCs, and the application of CD146 + MSCs in the treatment of specific diseases has also achieved better results. CD146 is also involved in mediating a variety of cellular signaling pathways, but whether it plays the same role in MSCs remains to be demonstrated by further experiments.
Conclusion: The utilization of CD146 + MSCs for tissue regeneration will be conducive to improving the therapeutic effect of MSCs.
目的: 总结 CD146 在 MSCs 中的表达情况及作用。.
方法: 广泛查阅国内外 CD146 相关研究文献，对其在 MSCs 中的表达情况及作用进行总结分析。.
结果: CD146 是一种介导细胞间或细胞与细胞外基质间黏附的跨膜蛋白，表达于多种 MSCs 表面。越来越多研究表明，CD146 + MSCs 比 CD146 - MSCs 或未分选 MSCs 具有更加优良的细胞特性，如更强的增殖、分化、迁移和免疫调节等能力。应用 CD146 + MSCs 治疗特定疾病也获得了更佳效果。CD146 还参与介导多种细胞信号通路，但其在 MSCs 中是否发挥同样的作用还需进一步实验证明。.
结论: 利用 CD146 + MSCs 进行组织和器官损伤修复将有利于提高 MSCs 的治疗效果。.
Keywords: CD146; heterogeneity; mesenchymal stem cells; regeneration; stem cell subset.