BAtCHing stem-like T cells during exhaustion

Nat Immunol. 2021 Mar;22(3):274-276. doi: 10.1038/s41590-021-00891-8.

Abstract

Long-term pathogen and tumor control as well as checkpoint immunotherapies rely on ‘stem-like’ CD8+ T cells. New results uncover BACH2 as a key regulator of this subpopulation and solve an important piece of the puzzle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Basic-Leucine Zipper Transcription Factors
  • CD8-Positive T-Lymphocytes*
  • Epigenesis, Genetic
  • Epigenomics
  • Stem Cells*

Substances

  • Basic-Leucine Zipper Transcription Factors