Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress

Hypertension. 2021 Apr;77(4):1212-1222. doi: 10.1161/HYPERTENSIONAHA.120.16175. Epub 2021 Mar 1.

Authors

Matthew J Rossman¹, Rachel A Gioscia-Ryan¹, Jessica R Santos-Parker¹, Brian P Ziemba¹, Kara L Lubieniecki¹, Lawrence C Johnson¹, Natalie E Poliektov¹, Nina Z Bispham¹, Kayla A Woodward¹, Erzsebet E Nagy¹, Nathan S Bryan², Julie A Reisz³, Angelo D'Alessandro³, Michel Chonchol⁴, Amy L Sindler¹, Douglas R Seals¹

Affiliations

¹ Department of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
² Baylor College of Medicine, Houston, TX (N.S.B.).
³ Department of Biochemistry and Molecular Genetics (J.A.R., A.D.), University of Colorado Anschutz Medical Campus, Aurora, CO.
⁴ Department of Medicine, Division of Renal Diseases and Hypertension (M.C.), University of Colorado Anschutz Medical Campus, Aurora, CO.

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT02393742.

Keywords: mitochondria; nitric oxide; oxidative stress; reactive oxygen species; sodium nitrite.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

Aged
Aging / physiology*
Animals
Biomarkers / analysis
Biomarkers / blood
Dietary Supplements
Drug Monitoring / methods
Endothelium, Vascular* / drug effects
Endothelium, Vascular* / metabolism
Female
Humans
Metabolomics / methods
Mice
Mitochondria* / drug effects
Mitochondria* / metabolism
Models, Animal
Oxidative Stress / physiology
Sodium Nitrite* / administration & dosage
Sodium Nitrite* / adverse effects
Sodium Nitrite* / blood
Treatment Outcome

Substances

Biomarkers
Sodium Nitrite

Associated data

ClinicalTrials.gov/NCT02393742

Grants and funding