Abstract
High-resolution tandem mass spectrometry (HR-MS2)-based metabolomic studies of Amycolatopsis saalfeldensis, isolated from the "Saalfelder Feengrotten" caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B-D (1-3) and the known saalfelduracin A (4). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amycolatopsis / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Antibiosis
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Caves / microbiology*
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Chromatography, High Pressure Liquid
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Coculture Techniques
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Germany
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Metabolomics
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Microbial Sensitivity Tests
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Molecular Structure
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Peptides / isolation & purification
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Peptides / pharmacology*
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Tandem Mass Spectrometry
Substances
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Anti-Infective Agents
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Biological Products
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Peptides
Supplementary concepts
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Amycolatopsis saalfeldensis