Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a "vicious circle" characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies.
Keywords: Aetiopathology multi-organ dysfunction; Ageing; Alzheimer; Biomarker panel; COVID-19; Cancer; Cardiovascular disease; Complementary medicine; Cost efficacy; Energy imbalance; Glaucoma; Health policy; Individualised patient profiling; Injury; Liquid biopsy; Mechanisms; Mitigating measures; Mitochondrial impairment; Molecular patterns; Multi-modal diagnostics; Multifactorial disease; Neurodegeneration; Origin; Outcomes; Oxidative stress; Patient stratification; Predictive preventive personalised medicine (PPPM/3PM); ROS; Repair; Reversible damage; Suboptimal health; Vasospasm; Vicious circle.
© The Author(s) 2021.