T helper 17 cells: A new actor on the stage of type 2 diabetes and aging?

Yi-Cheng Chang; Siow-Wey Hee; Lee-Ming Chuang

doi:10.1111/jdi.13541

T helper 17 cells: A new actor on the stage of type 2 diabetes and aging?

J Diabetes Investig. 2021 Jun;12(6):909-913. doi: 10.1111/jdi.13541. Epub 2021 Mar 24.

Authors

Yi-Cheng Chang^{1

2

3}, Siow-Wey Hee¹, Lee-Ming Chuang^{1

4

5}

Affiliations

¹ Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
² Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan.
³ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
⁴ Graduate Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan.
⁵ Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.

Abstract

Metformin improves mitochondrial function and enhances autophagy of T helper 17 cells, leading to decreased inflammation. This highlights the importance of metabolic modulation of immune cells.

Publication types

Review

MeSH terms

Aging / immunology*
Animals
Diabetes Mellitus, Type 2 / immunology*
Humans
Hypoglycemic Agents / pharmacology
Insulin Resistance / immunology*
Metformin / pharmacology
Mice
Th17 Cells / drug effects
Th17 Cells / immunology*

Substances

Hypoglycemic Agents
Metformin