Long-Term Azithromycin Maintenance Treatment in Patients with Frequent Exacerbations of Chronic Obstructive Pulmonary Disease

Sander Talman; Sevim Uzun; Remco S Djamin; Sara J Baart; Marco J J H Grootenboers; Joachim Aerts; Menno van der Eerden

doi:10.2147/COPD.S284397

Long-Term Azithromycin Maintenance Treatment in Patients with Frequent Exacerbations of Chronic Obstructive Pulmonary Disease

Int J Chron Obstruct Pulmon Dis. 2021 Mar 1:16:495-498. doi: 10.2147/COPD.S284397. eCollection 2021.

Authors

Sander Talman¹, Sevim Uzun², Remco S Djamin¹, Sara J Baart³, Marco J J H Grootenboers¹, Joachim Aerts², Menno van der Eerden²

Affiliations

¹ Amphia Hospital Breda, Department of Pulmonary Medicine, Breda, 4800RK, the Netherlands.
² Erasmus Medical Centre Rotterdam, Department of Pulmonary Medicine, Rotterdam, 3015 CE, the Netherlands.
³ Erasmuc Medical Centre Rotterdam, Department of Biostatistics, Rotterdam, 3015 CE, the Netherlands.

Abstract

Macrolides are effective in reducing the number of exacerbations in COPD patients with the frequent exacerbator phenotype. Our study did not show a persistent effect of azithromycin on exacerbation frequencies after more than one year of usage.

Keywords: COLUMBUS; COPD; Macrolide; exacerbations; long-term.

MeSH terms

Anti-Bacterial Agents / adverse effects
Azithromycin* / adverse effects
Disease Progression
Humans
Macrolides
Pulmonary Disease, Chronic Obstructive* / diagnosis
Pulmonary Disease, Chronic Obstructive* / drug therapy

Substances

Anti-Bacterial Agents
Macrolides
Azithromycin