Meningeal lymphatics prime tumor immunity in glioblastoma

Maya S Graham; Ingo K Mellinghoff

doi:10.1016/j.ccell.2021.02.012

Meningeal lymphatics prime tumor immunity in glioblastoma

Cancer Cell. 2021 Mar 8;39(3):304-306. doi: 10.1016/j.ccell.2021.02.012.

Authors

Maya S Graham¹, Ingo K Mellinghoff²

Affiliations

¹ Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: [email protected].

Abstract

The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain
Brain Neoplasms*
Glioblastoma* / genetics
Humans
Lymphatic Vessels*
Meninges

Abstract

Publication types

MeSH terms

Grants and funding