Linking ubiquitin to actin dynamics during cell fusion

Luca Lignitto; Michele Pagano

doi:10.1016/j.devcel.2021.02.012

Linking ubiquitin to actin dynamics during cell fusion

Dev Cell. 2021 Mar 8;56(5):569-570. doi: 10.1016/j.devcel.2021.02.012.

Authors

Luca Lignitto¹, Michele Pagano²

Affiliations

¹ Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
² Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: [email protected].

PMID: 33689766
DOI: 10.1016/j.devcel.2021.02.012

Abstract

Cell-cell fusion is essential to the development of multicellular organisms and is driven by remodeling of the actin cytoskeleton. In this issue of Developmental Cell, Rodríguez-Pérez et al. reveal how CRL3-dependent mono-ubiquitylation modulates cell fusion by controlling the dynamics of cytoskeletal rearrangements.

Publication types

Comment

MeSH terms

Actin Cytoskeleton
Actins*
Cell Fusion
Cytoskeleton
Ubiquitin*

Substances

Actins
Ubiquitin

Grants and funding

R35 GM136250/GM/NIGMS NIH HHS/United States