A neu(ronal) player joins the T regulatory game

Samantha B Larsen; Shruti Naik

doi:10.1016/j.immuni.2021.02.016

A neu(ronal) player joins the T regulatory game

Immunity. 2021 Mar 9;54(3):404-406. doi: 10.1016/j.immuni.2021.02.016.

Authors

Samantha B Larsen¹, Shruti Naik²

Affiliations

¹ Neuroscience Institute, New York University Langone Health, 550 First Avenue, New York, NY 10016, USA.
² Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology, and Perlmutter Cancer Center, New York University Langone Health, 550 First Avenue, New York, NY 10016, USA. Electronic address: [email protected].

PMID: 33691130
DOI: 10.1016/j.immuni.2021.02.016

Abstract

The enteric nervous system is surfacing as a key regulator of intestinal immunity and a liaison of host-commensal interactions. In this issue, Yan et al. identify neuronal interleukin-6 as a potent modulator of regulatory T (Treg) cells in the intestine. This neuroimmune dialog is further refined by commensal microbiota, which impact the enteric nervous system and consequently the intestinal Treg cell pool.

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MeSH terms

Enteric Nervous System*
Intestines
Microbiota*
Symbiosis
T-Lymphocytes, Regulatory