Peak glucose during an oral glucose tolerance test is associated with future diabetes risk in adults with cystic fibrosis

Aims/hypothesis: Cystic fibrosis-related diabetes (CFRD) affects up to 50% of adults with cystic fibrosis (CF) and its presence is associated with adverse effects on nutritional status and pulmonary function. Early diagnosis could minimise CFRD morbidity, yet current methods of an OGTT at 0 and 2 h yield unreliable results. Our aim was to determine which indices from a 2 h OGTT with sampling every 30 min might improve prediction of CFRD.

Methods: Cross-sectional analysis at baseline (n = 293) and observational prospective analysis (n = 185; mean follow-up of 7.5 ± 4.2 years) of the Montreal Cystic Fibrosis Cohort were performed. Blood glucose and insulinaemia OGTT variables were studied in relation to lung function (forced expiratory volume in 1 s [FEV1]), BMI and risk of developing CFRD.

Results: At baseline, maximum OGTT glucose (G_max) was negatively associated with FEV1 (p = 0.003). Other OGTT values, including classical 2 h glucose, were not. A higher G_max was associated with lower insulin secretory capacity, delayed insulin peak timing and greater pancreatic insufficiency (p < 0.01). G_max was positively associated with the risk of developing CFRD (p = 0.0029); no individual with a G_max < 8 mmol/l developed CFRD over the following decade. No OGTT variable correlated to the rate of change in BMI or FEV1.

Conclusions/interpretation: In adults with CF, G_max is strongly associated with the risk of developing CFRD; G_max < 8 mmol/l could identify those at very low risk of future CFRD. G_max is higher in individuals with pancreatic insufficiency and is associated with poorer insulin secretory capacity and pulmonary function.