Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation

Sarah Soueges; Claire Triffault-Fillit; Sandrine Roux; Hélène Labussière-Wallet; David Lebeaux; Oana Dumitrescu; Isabelle Morelec; Elisabeth Hodille; Florence Ader; Lyon HEMINF study group

doi:10.1007/s10096-021-04186-6

Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation

Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):2033-2036. doi: 10.1007/s10096-021-04186-6. Epub 2021 Mar 10.

Authors

Collaborators

Lyon HEMINF study group:
F Ader, V Alcazer, E Bachy, M Balsat, F Barraco, M Boccard, A Conrad, S Ducastelle-Leprêtre, O Dumitrescu, D Dupont, V Escuret, E Ferrant, T Ferry, E Frobert, H Ghesquières, L Karlin, H Labussière-Wallet, M-V Larcher, F Laurent, B Lina, G Lina, J Menotti, P Miailhes, G Monneret, F Morfin-Sherpa, T Perpoint, M Rabodonirina, M Renault, C Roure-Sobas, V Safar, G Salles, P Sesques, X Thomas, F Valour, F Venet, F Wallet, M Wallon

Affiliations

¹ Département des Maladies infectieuses et tropicales, Hospices Civils de Lyon, F-69004, Lyon, France.
² Département d'Hématologie clinique, Hospices Civils de Lyon, F-69495, Pierre-Bénite, France.
³ Université de Paris, 75006, Paris, France.
⁴ Service de Microbiologie, Unité Mobile D'Infectiologie, AP-HP, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France.
⁵ Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, F-69007, Lyon, France.
⁶ Institut des Agents Infectieux, Hospices Civils de Lyon, F-69004, Lyon, France.
⁷ Département de médecine nucléaire, Hospices Civils de Lyon, F-69495, Pierre-Bénite, France.
⁸ Département des Maladies infectieuses et tropicales, Hospices Civils de Lyon, F-69004, Lyon, France. [email protected].
⁹ Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Univ Lyon, F-69007, Lyon, France. [email protected].

PMID: 33694036
DOI: 10.1007/s10096-021-04186-6

Abstract

Nocardiosis is a life-threatening opportunistic infection in immunocompromised patients. Herein, we present successful adjunctive use of liposomal nebulized amikacin and tedizolid in a recipient of allogeneic hematopoietic stem cell transplantation infected with Nocardia nova complex who presented multiple complications to conventional therapeutic options.

Keywords: Allogeneic hematopoietic stem cell transplantation; Liposomal nebulized amikacin; Nocardiosis; Tedizolid.

Publication types

Case Reports

MeSH terms

Amikacin / pharmacology*
Anti-Bacterial Agents / therapeutic use*
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Immunosuppressive Agents / adverse effects
Liposomes / administration & dosage*
Liposomes / chemistry
Liposomes / therapeutic use
Male
Middle Aged
Nebulizers and Vaporizers
Nocardia / drug effects*
Nocardia Infections / diagnosis
Nocardia Infections / drug therapy*
Oxazolidinones / pharmacology*
Tetrazoles / pharmacology*
Time Factors

Substances

Anti-Bacterial Agents
Immunosuppressive Agents
Liposomes
Oxazolidinones
Tetrazoles
Amikacin
tedizolid

Supplementary concepts

Nocardia nova