Biological Function of HYOU1 in Tumors and Other Diseases

Shan Rao; Linda Oyang; Jiaxin Liang; Pin Yi; Yaqian Han; Xia Luo; Longzheng Xia; Jinguan Lin; Shiming Tan; Jiaqi Hu; Hui Wang; Lu Tang; Qing Pan; Yanyan Tang; Yujuan Zhou; Qianjin Liao

doi:10.2147/OTT.S297332

Biological Function of HYOU1 in Tumors and Other Diseases

Onco Targets Ther. 2021 Mar 5:14:1727-1735. doi: 10.2147/OTT.S297332. eCollection 2021.

Authors

Shan Rao¹, Linda Oyang¹, Jiaxin Liang¹, Pin Yi¹, Yaqian Han¹, Xia Luo¹, Longzheng Xia¹, Jinguan Lin¹, Shiming Tan¹, Jiaqi Hu¹, Hui Wang¹, Lu Tang^{1

2}, Qing Pan^{1

2}, Yanyan Tang¹, Yujuan Zhou¹, Qianjin Liao¹

Affiliations

¹ Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.
² University of South China, Hengyang, 421001, Hunan, People's Republic of China.

Abstract

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.

Keywords: HYOU1; anti-tumor immunity; endoplasmic reticulum; tumor.

Publication types

Review

Grants and funding

This work was supported in part by grants from the following sources: the National Natural Science Foundation of China (81972636, 81872281, 81772842), the Natural Science Foundation of Hunan Province (2020JJ5336, 2019JJ40175, 2019JJ40183 2018JJ1013), the Research Project of Health Commission of Hunan Province (202109031837, 20201020), China Hunan Provincial Science and Technology Department (2018SK7005), Ascend Foundation of National cancer center (NCC2018b68), and Supported By Hunan Cancer Hospital Climb Plan (ZX2020001-3, YF2020002) and By the Fundamental Research Funds for the Central Universities of Central South University (2019zzts832, 2019zzts833).