Impact of dose to lung outside the planning target volume on distant metastasis or progression after SBRT for early-stage non-small cell lung cancer

Ryan T Hughes; Cole R Steber; Travis J Jacobson; Michael K Farris

doi:10.1016/j.radonc.2021.03.004

Impact of dose to lung outside the planning target volume on distant metastasis or progression after SBRT for early-stage non-small cell lung cancer

Radiother Oncol. 2021 Jun:159:28-32. doi: 10.1016/j.radonc.2021.03.004. Epub 2021 Mar 9.

Authors

Ryan T Hughes¹, Cole R Steber², Travis J Jacobson², Michael K Farris²

Affiliations

¹ Department of Radiation Oncology, Wake Forest School of Medicine, Winston Salem, North Carolina, United States. Electronic address: [email protected].
² Department of Radiation Oncology, Wake Forest School of Medicine, Winston Salem, North Carolina, United States.

Abstract

Mean dose (EQD2) to 3-cm shell of lung surrounding the PTV was evaluated for association with distant metastasis and PFS after SBRT for stage I NSCLC. Dose was uniformly above previously determined threshold and metastasis was uncommon. An association between outcomes and mean EQD2 could not be confirmed or refuted.

Keywords: Lung cancer; Metastasis; Non-small cell lung cancer; Stereotactic body radiotherapy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Non-Small-Cell Lung* / surgery
Humans
Lung
Lung Neoplasms* / surgery
Radiosurgery*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted

Abstract

Publication types

MeSH terms

Grants and funding