Abstract
Seven patients developed acute hepatitis after receiving Plethoryl for obesity for 4 to 16 weeks. Jaundice was generally associated with or preceded by asthenia, nausea and pruritus. Serum aminotransferase activities were markedly increased whereas alkaline phosphatase and gamma-glutamyltransferase activities were moderately elevated. There was no hepatic failure. In all cases, Plethoryl administration was promptly discontinued. In 6 cases, jaundice disappeared within 2 to 4 weeks, and recovery occurred within 2 to 5 months. In one case, however, jaundice disappeared within 12 weeks and recovery took 10 months.
MeSH terms
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Acute Disease
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Adult
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Chemical and Drug Induced Liver Injury / etiology*
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Cyclohexanes / adverse effects*
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Cyclohexanones / adverse effects*
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Cyclohexanones / metabolism
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Diterpenes
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Drug Combinations / adverse effects
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Drug Combinations / metabolism
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Drug Interactions
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Female
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Humans
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Liver / metabolism
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Middle Aged
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Triiodothyronine / adverse effects
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Triiodothyronine / analogs & derivatives*
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Triiodothyronine / metabolism
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Vitamin A / adverse effects
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Vitamin A / analogs & derivatives*
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Vitamin A / metabolism
Substances
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Cyclohexanes
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Cyclohexanones
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Diterpenes
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Drug Combinations
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Triiodothyronine
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Plethoryl
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Vitamin A