Abstract
Hepatocellular carcinoma (HCC) is a common malignant tumor with a high morbidity and mortality in China and elsewhere in the world. Due to its tumor heterogeneity and distant metastasis, patients with HCC often have a poor prognosis. A surgical treatment such as a radical hepatectomy is still the treatment of choice for patients with HCC in current clinical practice. However, the high rate of recurrence and rate of metastasis after surgery diminishes the survival of and prognosis for these patients. In an era of targeted therapy and immunotherapy, the surgical treatment of HCC must change. This review focuses on the definition, feasibility, and criteria with which to evaluate neoadjuvant therapy for HCC in order to provide a new perspective on surgical treatment of HCC.
Keywords:
hepatocellular carcinoma; neoadjuvant therapy; surgical treatment.
Publication types
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Historical Article
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Review
MeSH terms
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Carcinoma, Hepatocellular / diagnosis
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Carcinoma, Hepatocellular / mortality
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Carcinoma, Hepatocellular / pathology
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Carcinoma, Hepatocellular / therapy*
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China / epidemiology
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Disease-Free Survival
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Feasibility Studies
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Hepatectomy / history
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Hepatectomy / standards
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Hepatectomy / statistics & numerical data
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Hepatectomy / trends*
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History, 20th Century
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History, 21st Century
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Humans
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Liver Neoplasms / diagnosis
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Liver Neoplasms / mortality
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Liver Neoplasms / pathology
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Liver Neoplasms / therapy*
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Medical Oncology / history
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Medical Oncology / standards
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Medical Oncology / statistics & numerical data
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Medical Oncology / trends
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Neoadjuvant Therapy / methods
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Neoadjuvant Therapy / standards
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Neoadjuvant Therapy / statistics & numerical data
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Neoadjuvant Therapy / trends*
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Neoplasm Recurrence, Local / epidemiology*
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Neoplasm Recurrence, Local / prevention & control
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Practice Guidelines as Topic
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Prognosis
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Time Factors