Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice

Cell Mol Immunol. 2021 Apr;18(4):1070-1073. doi: 10.1038/s41423-021-00658-z. Epub 2021 Mar 17.
No abstract available

Publication types

  • Letter

MeSH terms

  • Angiotensin-Converting Enzyme 2 / chemistry
  • Animals
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / immunology
  • CHO Cells
  • COVID-19 / immunology
  • COVID-19 / prevention & control*
  • COVID-19 Vaccines / genetics
  • COVID-19 Vaccines / immunology*
  • Cricetulus
  • Immunoglobulin Fc Fragments / genetics
  • Macaca fascicularis
  • Mice
  • Mice, Inbred BALB C
  • Molecular Docking Simulation
  • Protein Domains / immunology
  • SARS-CoV-2 / immunology*
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / immunology*
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / immunology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19 Vaccines
  • Immunoglobulin Fc Fragments
  • Spike Glycoprotein, Coronavirus
  • Vaccines, Synthetic
  • spike protein, SARS-CoV-2
  • Angiotensin-Converting Enzyme 2