Novel antihypertensives targeted at dopamine beta-monooxygenase: turnover-dependent cofactor depletion by phenyl aminoethyl selenide

J Med Chem. 1988 Jun;31(6):1066-8. doi: 10.1021/jm00401a003.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Ascorbic Acid / metabolism
  • Blood Pressure / drug effects
  • Chromaffin Granules / metabolism
  • Dopamine beta-Hydroxylase / antagonists & inhibitors*
  • Ethylamines / metabolism
  • Ethylamines / pharmacology*
  • Male
  • Organoselenium Compounds*
  • Rats
  • Rats, Inbred SHR

Substances

  • Antihypertensive Agents
  • Ethylamines
  • Organoselenium Compounds
  • phenyl-2-aminoethylselenide
  • Dopamine beta-Hydroxylase
  • Ascorbic Acid