Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series

Int J Gynecol Pathol. 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768.

Abstract

Ovarian seromucinous borderline tumors (SMBT) and clear cell tumors are both closely associated with endometriosis and share, in a proportion of cases, a molecular pathway involving ARID1A mutations, but they have been rarely described in association. We report a case series of 4 clear cell tumors (3 carcinomas, 1 borderline adenofibroma) coexisting in the same ovary with SMBT. In all cases, the SMBT was the predominant component and we highlight that adequate sampling of these tumors is important to detect small clear cell carcinomas, thus potentially altering the treatment and prognosis.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Mucinous / complications
  • Adenocarcinoma, Mucinous / diagnosis*
  • Adenocarcinoma, Mucinous / pathology
  • Adenofibroma / complications
  • Adenofibroma / diagnosis*
  • Adenofibroma / pathology
  • Adult
  • Aged
  • Carcinoma, Ovarian Epithelial / complications
  • Carcinoma, Ovarian Epithelial / diagnosis*
  • Carcinoma, Ovarian Epithelial / pathology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Endometriosis / complications
  • Endometriosis / diagnosis*
  • Endometriosis / pathology
  • Female
  • Humans
  • Middle Aged
  • Mutation
  • Ovarian Neoplasms / complications
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / pathology
  • Ovary / pathology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • ARID1A protein, human
  • DNA-Binding Proteins
  • Transcription Factors