Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults

Joshua M Schrock; Daniel T Ryan; Rana Saber; Nanette Benbow; Lauren A Vaught; Nina Reiser; Matthew P Velez; Ryan Hsieh; Michael Newcomb; Alexis R Demonbreun; Brian Mustanski; Elizabeth M McNally; Richard D'Aquila; Thomas W McDade

doi:10.1101/2021.03.11.21253421

Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults

medRxiv [Preprint]. 2021 Mar 12:2021.03.11.21253421. doi: 10.1101/2021.03.11.21253421.

Authors

Joshua M Schrock^{1

2

3}, Daniel T Ryan^{1

2}, Rana Saber^{1

2}, Nanette Benbow⁴, Lauren A Vaught^{5

6}, Nina Reiser^{5

6}, Matthew P Velez^{5

6}, Ryan Hsieh^{5

6}, Michael Newcomb^{1

2}, Alexis R Demonbreun^{5

7}, Brian Mustanski^{1

2}, Elizabeth M McNally^{5

6

8}, Richard D'Aquila⁹, Thomas W McDade^{3

10}

Affiliations

¹ Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
² Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
³ Department of Anthropology, Northwestern University.
⁴ Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine.
⁵ Center for Genetic Medicine, Northwestern University.
⁶ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine.
⁷ Department of Pharmacology, Northwestern University Feinberg School of Medicine.
⁸ Department of Biochemistry and Molecular Genetics, Northwestern University.
⁹ Division of Infectious Diseases, Dept. of Medicine, Northwestern University Feinberg School of Medicine.
¹⁰ Institute for Policy Research, Northwestern University.

Abstract

Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), we found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).

Publication types

Preprint

Grants and funding

UL1 TR001422/TR/NCATS NIH HHS/United States