FENDRR: A pivotal, cancer-related, long non-coding RNA

Qingyuan Zheng; Qiyao Zhang; Xiao Yu; Yuting He; Wenzhi Guo

doi:10.1016/j.biopha.2021.111390

FENDRR: A pivotal, cancer-related, long non-coding RNA

Biomed Pharmacother. 2021 May:137:111390. doi: 10.1016/j.biopha.2021.111390. Epub 2021 Feb 16.

Authors

Qingyuan Zheng¹, Qiyao Zhang¹, Xiao Yu¹, Yuting He², Wenzhi Guo³

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China.
² Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China. Electronic address: [email protected].
³ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China. Electronic address: [email protected].

PMID: 33761608
DOI: 10.1016/j.biopha.2021.111390

Abstract

Long non-coding RNAs (lncRNAs) have more than 200 nucleotides and do not encode proteins. Based on numerous studies, lncRNAs have emerged as new and crucial regulators of biological function and have been implicated in the pathogenesis of a variety of diseases, especially cancers. Specific lncRNAs have been identified as novel molecular biomarkers for cancer diagnosis, prognosis, and treatment efficacy. Fetal-lethal non-coding developmental regulatory RNA (FENDRR, also known as FOXF1-AS1) is a novel lncRNA that is located at chr3q13.31 and has four exons and 3099 nucleotides, and its genomic site is located at chr3q13.31. FENDRR is abnormally expressed in a variety of cancers and is significantly associated with different clinical characteristics. In addition, FENDRR has shown potential as a biomarker for cancer diagnosis, prognosis, and treatment. In this review, we summarize the current understanding of FENDRR and its mechanistic role in cancer progression. We also discuss recent insights into the clinical significance of FENDRR for cancer diagnosis, prognosis, and treatment.

Keywords: Biomarker; Cancer; FENDRR; LncRNA; Therapeutic target.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Biomarkers, Tumor
Forkhead Transcription Factors / genetics*
Humans
Neoplasms / diagnosis
Neoplasms / drug therapy
Neoplasms / genetics*
RNA, Long Noncoding / drug effects
RNA, Long Noncoding / genetics*

Substances

Antineoplastic Agents
Biomarkers, Tumor
FOXF1 protein, human
Forkhead Transcription Factors
RNA, Long Noncoding