Herein we present a new biomaterial based on cellulose, collagen and sodium alginate which served as a matrix for the incorporation of bioactive substances with antioxidant properties. Compared with pure cellulose hydrogels, the compressive strength and the elastic modulus of cellulose-collagen-alginate hydrogels were significantly enhanced, thus the compressive strength increased from 0.256 kPa to 6.91 kPa, while the elastic modulus increased from 0.0023 kPa to 0.115 kPa at 30% strain level. The release kinetic of all drugs through matrix components was done according to the Korsmeyer-Peppas model with a Fickian diffusion. The presence of bioactive principles, quercetin, lipoic acid and anthocyanins, gives biomaterials an antioxidant capacity on average 30% higher compared to the base matrix. The mechanical resistance, mucoadhesiveness, bioadhesiveness, release kinetic, and antioxidant capacity of active principles, recommend these biomaterials for the manufacture of transdermal drug delivery devices.
Keywords: Alginic acid; Cellulose; Collagen; Hibiscus sabdariffa; Lipoic acid; Quercetin.
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