Dirty mice join the immunologist's toolkit

Meggie Kuypers; Tijana Despot; Thierry Mallevaey

doi:10.1016/j.micinf.2021.104817

Dirty mice join the immunologist's toolkit

Microbes Infect. 2021 Jul-Aug;23(6-7):104817. doi: 10.1016/j.micinf.2021.104817. Epub 2021 Mar 27.

Authors

Meggie Kuypers¹, Tijana Despot¹, Thierry Mallevaey²

Affiliations

¹ Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
² Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada. Electronic address: [email protected].

PMID: 33785421
DOI: 10.1016/j.micinf.2021.104817

Abstract

The microbiota is a driving force that influences host physiological functions. In this review, we discuss some of the methods that have been used in the pursuit of relevant host-microbiota interactions that control immune fitness and disease susceptibility, with a focus on dirty mice which have been recently incorporated in the immunologist's toolkit.

Keywords: Antibiotics; Germ-free mice; Microbiota; Pet store mice; Wild mice.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Germ-Free Life
Humans
Immunity
Mice / immunology*
Mice / microbiology*
Microbiota*

Grants and funding

363664/CIHR/Canada