Abstract
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.
MeSH terms
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Aged
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Biopsy
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Dementia / drug therapy*
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Female
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Humans
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Liver / drug effects
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Liver / pathology
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Microscopy, Electron
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Pantothenic Acid / adverse effects
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Pantothenic Acid / analogs & derivatives*
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Pantothenic Acid / antagonists & inhibitors*
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Pantothenic Acid / therapeutic use
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Reye Syndrome / chemically induced*
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Reye Syndrome / pathology
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gamma-Aminobutyric Acid / adverse effects
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / therapeutic use
Substances
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pantogab
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Pantothenic Acid
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gamma-Aminobutyric Acid