Eruptive Xanthoma With Dermal Mucin Deposition

Am J Dermatopathol. 2021 Aug 1;43(8):583-584. doi: 10.1097/DAD.0000000000001863.

Abstract

Xanthomas present clinically as eruptive, tuberoeruptive, tuberous, tendinous, or planar forms. Among these, eruptive xanthoma (EX) is characterized by sudden development of multiple, red-to-yellow papules, each less than 5 mm in diameter, on the extensor surface of the extremities and the buttock area. EX is often associated with severe hypertriglyceridemia, underlying diabetes, obesity, or excessive alcohol intake. Histologically EX is characterized by foamy cells, which are lipid-laden macrophages surrounded by lymphoid cells, histiocytes, and neutrophils; however, mucin deposition is not a typical feature. Herein, we report a rare case of xanthoma with diffuse, abundant mucin deposition.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Biopsy
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Humans
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / diagnosis*
  • Male
  • Skin / pathology
  • Skin Diseases / etiology
  • Skin Diseases / pathology*
  • Xanthomatosis / etiology
  • Xanthomatosis / pathology*