Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

María Magallón; Sara Pastor; Ana Esther Carrión; Lucía Bañuls; Daniel Pellicer; Silvia Castillo; Sergio Bondía; María Mercedes Navarro-García; Cruz González; Francisco Dasí

doi:10.3390/jcm10061268

Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

J Clin Med. 2021 Mar 18;10(6):1268. doi: 10.3390/jcm10061268.

Authors

María Magallón^#^{1

2}, Sara Pastor^#^{1

2}, Ana Esther Carrión^{1

2}, Lucía Bañuls^{1

2}, Daniel Pellicer^{1

2}, Silvia Castillo^{2

3}, Sergio Bondía², María Mercedes Navarro-García², Cruz González^{2

4}, Francisco Dasí^{1

2}

Affiliations

¹ Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain.
² Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain.
³ Paediatrics Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez, 17, 46010 Valencia, Spain.
⁴ Pneumology Unit, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez, 17, 46010 Valencia, Spain.

^# Contributed equally.

Abstract

Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

Keywords: Alpha-1 antitrypsin deficiency; antioxidant therapies; cystic fibrosis; endoplasmic reticulum stress; idiopathic pulmonary fibrosis; oxidative stress; primary ciliary dyskinesia; rare respiratory diseases.

Publication types

Review

Abstract

Publication types

Grants and funding