Endoscopic Retrograde Cholangio Pancreaticography (ERCP) is an invasive procedure which can be used for therapeutic purpose. But it has versatile complications. It depends upon patient factors and gastroenterologist's expertise. This study was done to determine factors affecting morbidity and mortality after ERCP for obstructive jaundice. The prospective observational study was conducted among 30 patients with obstructive jaundice in the department of Gastroenterology and Surgery of Combined Military Hospital (CMH), Dhaka during the period of July 2016 to December 2016. After obtaining a detailed history, general physical and systemic examinations were done for all enrolled patients and they were subjected to do relevant investigations. The data were collected by the active participation of the patient and patient was interviewed by the preformed case record form. ERCPs were carried out in a standard fashion by using a side viewing duodenoscope. Every variable like number of pancreatic duct cannulation, sphincterotomy, whether pre-cut or wire guided cannulation, number of failed removal of CBD stone and incomplete drainage was recorded by a trained assistant. The data analysis of 30 patients yielded that mean age of patient was 43.8 years. Most of the patients (50.0%) were in 41-60 years of age group. Among the respondents, 90.0% were male and 10.0% were female. The most common indication of ERCP was sphincterotomy with stone extraction (66.7%). About one tenth of study patients, 3(10.0%) developed post ERCP complications. The most common post ERCP complications were intra-procedural bleeding (66.7%) followed by pancreatitis (33.3%). Both of the complications were in mild form. In multivariate analysis it was found that history of acute pancreatitis, suspected SOD, needle knife and supra-papillary fistulotomy had more risks. Three (10.0%) patients developed complications, among which 66.7% had intra-procedural bleeding and 33.3% had pancreatitis. Middle aged person, male gender, precut sphincterotomy and history of acute pancreatitis are the commonest significant post ERCP morbidity and mortality predictors.