Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype

Catena Kresbach; Mario M Dorostkar; Abigail K Suwala; Annika K Wefers; Leonille Schweizer; Lara Engertsberger; Brigitte Bison; Martin Mynarek; Katja Kloth-Stachnau; Michael Spohn; Andreas von Deimling; Martin Benesch; Christian Hagel; Viktor-F Mautner; Stefan Rutkowski; Ulrich Schüller

doi:10.1007/s00401-021-02304-4

Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype

Acta Neuropathol. 2021 Jun;141(6):971-974. doi: 10.1007/s00401-021-02304-4. Epub 2021 Apr 12.

Authors

Catena Kresbach^{1

2}, Mario M Dorostkar^{3

4}, Abigail K Suwala^{5

6}, Annika K Wefers^{1

2

7}, Leonille Schweizer⁸, Lara Engertsberger⁹, Brigitte Bison¹⁰, Martin Mynarek¹, Katja Kloth-Stachnau¹, Michael Spohn^{1

2

11}, Andreas von Deimling^{5

6}, Martin Benesch⁹, Christian Hagel⁷, Viktor-F Mautner¹², Stefan Rutkowski¹, Ulrich Schüller^{13

14

15}

Affiliations

¹ Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), 20251, Hamburg, Germany.
³ Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.
⁴ German Center for Neurodegenerative Diseases, Munich, Germany.
⁵ Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
⁶ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
⁸ Institute for Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
⁹ Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
¹⁰ Department of Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Augsburg, Germany.
¹¹ Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹² Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
¹³ Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [email protected].
¹⁴ Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), 20251, Hamburg, Germany. [email protected].
¹⁵ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [email protected].

No abstract available

Publication types

Letter

MeSH terms

Adolescent
Adult
Central Nervous System Neoplasms* / diagnostic imaging
Central Nervous System Neoplasms* / genetics
Central Nervous System Neoplasms* / pathology
Child
Child, Preschool
DNA Methylation / genetics
Ependymoma* / diagnostic imaging
Ependymoma* / genetics
Ependymoma* / pathology
Female
Genes, Neurofibromatosis 2
Humans
Magnetic Resonance Imaging
Male
Mutation
Neurofibromatosis 2* / complications
Neurofibromatosis 2* / genetics
Neurofibromatosis 2* / pathology