Objective: To investigate the relationship between serum C1q tumor necrosis factor-related protein 9 (CTRP9) level and the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).
Objective: A total of 291 patients with T2DM underwent fundus examination, and their serum levels of CTRP9, insulin and adiponectin were measured using enzyme- linked immunosorbent assay. According to results of fundus examination, the patients were divided into DR group and non-DR (NDR) group, and logistic regression was used to analyze the relationship between serum CTRP9 levels and DR in T2DM patients.
Objective: Compared with those in NDR group, the patients with DR showed significantly increased serum CTRP9 level (P < 0.001) and decreased serum adiponectin level (P < 0.001). Pearson correlation analysis showed that in patients with T2DM complicated by DR, serum CTRP9 levels had a significant positive correlation with DR stage (P < 0.05) and a negative correlation with serum adiponectin level (P < 0.001). Multivariate logistic regression analysis showed that with the increase of serum CTRP9 level, the risk of DR is significantly increased in patients with T2DM.
Objective: In patients with T2DM complicated by DR, an increased serum CTRP9 level suggests a compensatory response to DR.
目的: 探讨2型糖尿病(T2DM)患者血清C1q肿瘤坏死因子相关蛋白9(CTRP9)水平与糖尿病视网膜病变(DR)的关系。
方法: 根据纳入标准收集291例T2DM患者临床资料，按照眼底检查结果分为DR组与非DR (NDR)组，ELISA法检测血清CTRP9、脂联素及胰岛素水平。统计分析血清CTRP9水平与T2DM患者、T2DM并发DR患者临床资料的相关性，探讨血清CTRP9水平与T2DM患者并发DR的关系。
结果: 与NDR组相比，DR组血清CTRP9水平显著升高(P < 0.001);血清脂联素水平显著降低(P < 0.001)。Pearson相关性分析显示T2DM并发DR患者中，血清CTRP9水平与DR严重程度呈显著正相关(P < 0.05);与血清脂联素水平呈负相关(P=0.017)。多元Logistic回归分析校正年龄、性别、体重指数、糖尿病病程、糖化血红蛋白、空腹血糖、空腹胰岛素、HOMA-IR、高血压病史、收缩压、低密度脂蛋白、甘油三酯等混杂因素，随着血清CTRP9水平的升高，T2DM并发DR的风险显著升高(P < 0.001)。
结论: T2DM并发DR患者血清CTRP9水平升高可能是糖尿病视网膜微血管病变的代偿反应。
Keywords: C1q tumor necrosis factor-related protein 9; diabetes mellitus, type 2; diabetic retinopathy.