ATAC-ing human tissue Treg cells

Maren Köhne; Marc Beyer

doi:10.1016/j.immuni.2021.03.014

ATAC-ing human tissue Treg cells

Immunity. 2021 Apr 13;54(4):605-607. doi: 10.1016/j.immuni.2021.03.014.

Authors

Maren Köhne¹, Marc Beyer²

Affiliations

¹ Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Electronic address: [email protected].
² Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, 53127 Bonn, Germany. Electronic address: [email protected].

PMID: 33852825
DOI: 10.1016/j.immuni.2021.03.014

Abstract

What defines regulatory T (Treg) cells in healthy human tissues? In this issue of Immunity, Delacher et al. describe a human follicular helper T cell-like tissue-repair Treg cell signature governed by BATF based on chromatin accessibility data and link this on a transcriptome and protein level to important functional features like CCR8 expression.

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MeSH terms

Chromatin*
Humans
T-Lymphocytes, Regulatory*
Transcriptome

Substances

Chromatin